Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 51 Researches
8
USERS' SCORE
Moderately Good
Based on 47 Reviews
7.9
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Read More
9
We aimed to understand whether probiotics could ease inflammation in autoimmune pancreatitis (AIP) by interfacing with innate immunity. We set up a mouse model of AIP and treated these mice with Lactobacillus gasseri. The treatment appeared to significantly reduce pancreatitis symptoms, potentially via TLR7 signaling in immune cells.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
Read More
Most Useful Reviews
9
Pain relief achieved
107 people found this helpful
Since taking one NATOOSHCHAK capsule each morning, my chronic colitis pain and swelling have decreased significantly. These enteric capsules are a major plus, and I ensure to keep them refrigerated for longevity. I've noticed great health benefits.
Read More
9
Improved digestion
29 people found this helpful
These probiotics significantly improved my digestive health. I had struggled with diets and irregularity, but since starting them, my body functions much better, and my skin is clearer. I recommend these; they have effectively solved my issues!
Read More
9
Nausea alleviated
18 people found this helpful
I took these probiotics to deal with occasional nausea and digestive rejection. They worked wonders in just half an hour, easing all negative symptoms. I'm quite impressed and plan to order them again.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 51 Researches
8
- All Researches
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
Read More
9
We examined how probiotics affect immune cells in rheumatoid arthritis (RA) patients. By isolating monocytes from both RA patients and healthy individuals, we created macrophages that were treated with different probiotic bacteria.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Read More
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Read More
9
We investigated how diet influences autoimmune diseases, particularly using a ketogenic diet (KD) model. The KD improved conditions in a mouse model of multiple sclerosis by interacting with the gut microbiome.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Read More
9
We aimed to understand whether probiotics could ease inflammation in autoimmune pancreatitis (AIP) by interfacing with innate immunity. We set up a mouse model of AIP and treated these mice with Lactobacillus gasseri. The treatment appeared to significantly reduce pancreatitis symptoms, potentially via TLR7 signaling in immune cells.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 47 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief achieved
107 people found this helpful
Since taking one NATOOSHCHAK capsule each morning, my chronic colitis pain and swelling have decreased significantly. These enteric capsules are a major plus, and I ensure to keep them refrigerated for longevity. I've noticed great health benefits.
Read More
9
Improved digestion
29 people found this helpful
These probiotics significantly improved my digestive health. I had struggled with diets and irregularity, but since starting them, my body functions much better, and my skin is clearer. I recommend these; they have effectively solved my issues!
Read More
9
Nausea alleviated
18 people found this helpful
I took these probiotics to deal with occasional nausea and digestive rejection. They worked wonders in just half an hour, easing all negative symptoms. I'm quite impressed and plan to order them again.
Read More
10
Balanced digestion restored
15 people found this helpful
Despite being sceptical about these probiotics affecting my IBS, they worked wonders! I felt relief from unpleasant symptoms within 30 minutes. They’re now part of my regular routine, and I’m grateful for the sample that introduced me to them.
Read More
9
Diarrhoea stopped
11 people found this helpful
After suffering from a lifetime of diarrhoea linked to my autoimmune disorder, these probiotics were transformative. Doubling the recommended dose resulted in perfectly normal poops and resolved my issues, even helping a friend with constipation. I plan to reorder soon.
Read More
Frequently Asked Questions
9
Nausea alleviated
18 people found this helpful
I took these probiotics to deal with occasional nausea and digestive rejection. They worked wonders in just half an hour, easing all negative symptoms. I'm quite impressed and plan to order them again.
10
Balanced digestion restored
15 people found this helpful
Despite being sceptical about these probiotics affecting my IBS, they worked wonders! I felt relief from unpleasant symptoms within 30 minutes. They’re now part of my regular routine, and I’m grateful for the sample that introduced me to them.
9
Discomfort relief
5 people found this helpful
Some time ago, I experienced unpleasant sensations on my left side and found my calprotectin level was 10 times higher than normal. Following a colonoscopy, I was diagnosed with sigmaiditis, an autoimmune disorder. My doctor advised taking probiotics alongside prebiotics. I ordered a probiotic supplement, and within a week, my discomfort disappeared, and my bowel movements improved. My life has significantly improved since then.
9
Symptom relief
5 people found this helpful
After numerous doctor visits for acid reflux, I decided to try this product following my cousin's recommendation. Within a week or two, I experienced relief. I'm now a strong believer in it and have reordered, sharing my success with friends having similar issues.
9
Diarrhoea stopped
11 people found this helpful
After suffering from a lifetime of diarrhoea linked to my autoimmune disorder, these probiotics were transformative. Doubling the recommended dose resulted in perfectly normal poops and resolved my issues, even helping a friend with constipation. I plan to reorder soon.
7.5
Bloating solution
2 people found this helpful
I ordered these probiotics at my husband’s request. Despite being a skeptic, he acknowledges their benefits in managing his bloating from an autoimmune disorder. Nutritional experts recommend probiotics for everyone, and my husband takes them on an empty stomach for optimal digestion.
9
Pain relief achieved
107 people found this helpful
Since taking one NATOOSHCHAK capsule each morning, my chronic colitis pain and swelling have decreased significantly. These enteric capsules are a major plus, and I ensure to keep them refrigerated for longevity. I've noticed great health benefits.
9
Miraculous effect
2 people found this helpful
After suffering from diarrhoea for two months due to an autoimmune disorder, I decided to try these probiotics. The previous treatments failed, but this product worked remarkably! I now take four tablets if I have gastrointestinal issues, and it consistently helps. I’ve been repurchasing it since.
9
Improved digestion
29 people found this helpful
These probiotics significantly improved my digestive health. I had struggled with diets and irregularity, but since starting them, my body functions much better, and my skin is clearer. I recommend these; they have effectively solved my issues!
7.5
Cold frequency declined
29 people found this helpful
After trying various probiotics with no luck, I found Jarrow Formulas. Since incorporating them, my frequent colds and poor skin have improved significantly. I now take them annually and feel much better overall.
2
Not effective
21 people found this helpful
The effect was not satisfactory. I often consume bifidobacteria but found this product lacking. I experienced discomfort with gas accumulation while using it. I will look for other options for my autoimmune disorder.
7.5
Constipation relief
5 people found this helpful
These probiotics are excellent for addressing constipation and bloating. I initially took three daily but have since reduced to two, which keeps me comfortable without any pain or cramps. I highly recommend them.
8
Lactobacillus modifies inflammation in lupus
We investigated the effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on immune responses in newly diagnosed systemic lupus erythematosus patients. By examining blood-derived macrophages, we observed that these probiotics can decrease key inflammatory markers and promote a healthier balance in macrophage populations. Notably, they lowered certain harmful cytokines while increasing beneficial ones in both lupus patients and healthy individuals. Although the probiotics showed promise in inducing an anti-inflammatory profile, their overall effectiveness in managing SLE aspects needs further exploration.
8
Lactobacillus enhances MSCs in lupus
We investigated how Lactobacillus probiotics affect mesenchymal stem/stromal cells (MSCs) in a lupus-like disease model. Using a pristane-induced lupus model in mice, we co-incubated naïve MSCs with Lactobacillus rhamnosus and Lactobacillus delbrueckii. Our findings revealed that L. rhamnosus significantly enhances MSCs' immunomodulatory functions, showing promise in alleviating lupus symptoms. However, the overall effects varied, with L. delbrueckii showing less impact. These results encourage further exploration into using probiotics as a complementary approach for treating lupus.
9
We examined how probiotics affect immune cells in rheumatoid arthritis (RA) patients. By isolating monocytes from both RA patients and healthy individuals, we created macrophages that were treated with different probiotic bacteria.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
8
We explored how Lactobacillus rhamnosus affects inflammation in rheumatoid arthritis (RA) patients. Involving 89 participants, the study monitored various clinical factors and examined how this probiotic influenced CD8 T cells. Remarkably, we observed that L. rhamnosus reduced pro-inflammatory markers and supported a shift in T cell behavior. This suggests that it may help improve treatment for RA by calming inflammation and encouraging a more balanced immune response.
8
Lactobacillus shows promise for therapy
We explored the therapeutic effects of Lactobacillus and Bifidobacterium on a rat model of demyelination, aiming to understand how gut bacteria influence inflammatory disorders like multiple sclerosis.
In our study, we found that supplementing with these lactic acid bacteria greatly improved behavioral deficits and reduced demyelination.
Additionally, the treatments helped lower oxidative stress and enhanced serum levels of vitamins D and B. These promising results suggest that incorporating Lactobacillus may serve as a supportive therapy for conditions like multiple sclerosis.
In our study, we found that supplementing with these lactic acid bacteria greatly improved behavioral deficits and reduced demyelination.
Additionally, the treatments helped lower oxidative stress and enhanced serum levels of vitamins D and B. These promising results suggest that incorporating Lactobacillus may serve as a supportive therapy for conditions like multiple sclerosis.
8
We conducted a randomized, double-blind study to see how synbiotics could influence systemic lupus erythematosus (SLE) disease activity. Fifty patients were split into two groups—one received standard care and synbiotics, while the other had standard care only.
The results were promising; the synbiotics group showed a notable decrease in inflammatory markers and disease activity compared to their initial conditions. Meanwhile, the placebo group didn't see significant changes.
While our findings suggest synbiotics could be a helpful addition to SLE treatment, more research is necessary to understand how they work.
The results were promising; the synbiotics group showed a notable decrease in inflammatory markers and disease activity compared to their initial conditions. Meanwhile, the placebo group didn't see significant changes.
While our findings suggest synbiotics could be a helpful addition to SLE treatment, more research is necessary to understand how they work.
References
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- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. doi:10.1007/s12017-025-08837-1
- Qu H, Fu XX, Han S. C16 peptide and angiopoietin-1 alleviate the side effects of glucocorticoids in a rat multiple sclerosis model. Life Sci. 2025;363:123402. doi:10.1016/j.lfs.2025.123402
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- Straus Farber R, Walker EL, Diallo F, Onomichi K, Riley C, et al. A randomized cross-over trial of prebiotics and probiotics in multiple sclerosis: Trial feasibility, supplement tolerability and symptom abatement. Mult Scler Relat Disord. 2024;89:105762. doi:10.1016/j.msard.2024.105762
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- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. doi:10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. doi:10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. doi:10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. doi:10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. doi:10.3389/fmed.2023.1085578
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- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. doi:10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. doi:10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. doi:10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. doi:10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. doi:10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. doi:10.1002/jcp.26819
- Piva F, Gervois P, Karrout Y, Sané F, Romond MB. Gut-Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients. 2023;15. doi:10.3390/nu15234861
- Huo D, Cen C, Chang H, Ou Q, Jiang S, et al. Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis. Commun Biol. 2021;4:1046. doi:10.1038/s42003-021-02587-z
- Li D, Cheng J, Zhu Z, Catalfamo M, Goerlitz D, et al. Treg-inducing capacity of genomic DNA of subsp. . Allergy Asthma Proc. 2020;41:372. doi:10.2500/aap.2020.41.200064
- Shi P, Qu H, Nian D, Chen Y, Liu X, et al. Treatment of Guillain-Barré syndrome with Bifidobacterium infantis through regulation of T helper cells subsets. Int Immunopharmacol. 2018;61:290. doi:10.1016/j.intimp.2018.06.015
- Laparra JM, Olivares M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 ameliorates gliadin-induced alterations in liver iron mobilisation. Br J Nutr. 2013;110:1828. doi:10.1017/S0007114513001098
- Laparra JM, Olivares M, Gallina O, Sanz Y. Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model. PLoS One. 2012;7:e30744. doi:10.1371/journal.pone.0030744
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. doi:10.3389/fimmu.2025.1518181
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. doi:10.3389/fendo.2022.754401
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. doi:10.1016/j.nut.2021.111282
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. doi:10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. doi:10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. doi:10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. doi:10.1111/j.1365-2249.2008.03788.x
- Qian S, Zhang X, Zheng X, Li R, Hao X, et al. Development of interleukin-27 recombinant Lactococcus lactis and its efficacy in treating psoriasis and colitis in mice. Int J Biol Macromol. 2024;282:137113. doi:10.1016/j.ijbiomac.2024.137113
- Akgul A, Freguia CF, Maddaloni M, Hoffman C, Voigt A, et al. Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease. Sci Rep. 2023;13:19489. doi:10.1038/s41598-023-46557-3
- Mathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, et al. A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab. Diabetologia. 2024;67:27. doi:10.1007/s00125-023-06014-2
- Sassi G, Licata G, Ventriglia G, Wouters A, Lemaitre P, et al. A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis-Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes. Diabetes. 2023;72:1470. doi:10.2337/db22-0852
- Guimaraes MAF, Pinheiro-Rosa N, Oliveira RP, Aguiar SLF, Miranda MCG, et al. Hsp65-producing Lactococcus lactis inhibits experimental autoimmune encephalomyelitis by preventing cell migration into spinal cord. Cell Immunol. 2023;384:104661. doi:10.1016/j.cellimm.2022.104661
- Nelson AS, Akgul A, Maddaloni M, Bhagyaraj E, Hoffman C, et al. Oral probiotic promotes indoleamine 2,3-dioxygenase- and TGF-β-Producing plasmacytoid dendritic cells to initiate protection against type 1 diabetes. Immunol Lett. 2021;239:12. doi:10.1016/j.imlet.2021.07.009
- Akgul A, Maddaloni M, Jun SM, Nelson AS, Odreman VA, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99. doi:10.1186/s13075-021-02475-1
- Preisser TM, da Cunha VP, Santana MP, Pereira VB, Cara DC, et al. Recombinant Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model. J Diabetes Res. 2021;2021:6697319. doi:10.1155/2021/6697319
- Gusmao-Silva G, Aguiar SLF, Miranda MCG, Guimarães MA, Alves JL, et al. Hsp65-Producing Prevents Antigen-Induced Arthritis in Mice. Front Immunol. 2020;11:562905. doi:10.3389/fimmu.2020.562905
- Cook DP, Cunha JPMCM, Martens PJ, Sassi G, Mancarella F, et al. Intestinal Delivery of Proinsulin and IL-10 via Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis. Front Immunol. 2020;11:1103. doi:10.3389/fimmu.2020.01103
- Nelson AS, Maddaloni M, Abbott JR, Hoffman C, Akgul A, et al. Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice. Sci Rep. 2020;10:6156. doi:10.1038/s41598-020-62881-4
- Maddaloni M, Kochetkova I, Hoffman C, Pascual DW. Delivery of IL-35 by Ameliorates Collagen-Induced Arthritis in Mice. Front Immunol. 2018;9:2691. doi:10.3389/fimmu.2018.02691
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- Kasarełło K, Szczepankowska A, Kwiatkowska-Patzer B, Lipkowski AW, Gadamski R, et al. Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. Folia Neuropathol. 2016;54:249.
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